Tissue Cross Reactivity (TCR) Services For Monoclonal Antibody Characterization

Testing the tissue cross-reactivity (TCR) of a monoclonal antibody is necessary to ensure that the antibody does not bind to receptors or other epitopes as well as to the intended target. Human tissues are used to determine the ability of a monoclonal antibody to bind to non-target epitopes. MDS‘s TCR services include:

• Providing specific study protocols to reflect your exact requirements.
• Sectioning and staining of a full range of frozen, resin and paraffin samples.
• Fully validated viable human donor tissue banks (up to 38 tissues) from multiple donors (minimum of 3 donors), with patient history if required.
• The ability to conjugate primary monoclonal antibodies if required.
• A full range of positive, negative and specific absorption assay controls to ensure technical validity.
• Evaluation of results by board certified pathologists.
• A flexible reporting process designed to meet your exact requirements with both standard and digitized photographic images in hard-copy GLP audited reports.
• Providing digital photographic images that can be electronically transferred to your desktop in real time.
• Fully audited Quality Assurance programs covering technical procedures and reporting refined to your regulatory requirements.