In Vivo ADME and PK Studies

Absorption, Distribution, Metabolism and Excretion (ADME) studies are a vital part of the comprehensive safety evaluation of a new chemical entity. MDS offers ADME studies in small animals using radio-labeled materials that you provide or MDS synthesizes for you. Routes of administration include oral, intravenous, dermal, intraperitoneal, inhalation, intrathecal and infusion as well as other intended delivery methods for your compound. These in-life studies provide information for:

• Metabolite isolation and characterization
• Bioavailability evaluations
• Bioequivalence studies
• Formulation screening and optimization
• Dosing frequency
• Routes of administration
• Exposure
• Interspecies comparisons